There are approximately 113 different cannabinoids that have been isolated from cannabis, and those that have been studied exhibit a variety of effects 1. In the marketplace, we have access to about six: THC, CBD, THCa, CBDa, CBN, and CBG. As technology improves and companies mature, new products featuring additional cannabinoids are beginning to become available, including products with delta-8 THC, THCv, and CBC. This blog will focus on CBG.
There is little research exploring the effects of CBG—research is currently limited to in vitro (tests done in test tubes, culture dishes, or anywhere outside of a living organism) and in rodent models—there exists no clinical research in humans. One reason that so little research exists is that CBG is not typically found in high concentrations in dried or cured cannabis plants, except in industrial hemp varieties 2.
The data that is available suggests that CBG might be effective at treating the following conditions:
A study published in 20133 stated that CBG has anti-inflammatory properties and that it could be considered as a treatment for patients suffering from intestinal bowel disease.
A 2009 study4 demonstrated that CBG might have therapeutic potential for the treatment of glaucoma as it might increase fluid drainage and decrease pressure in the eye.
In a study completed in early 20155 CBG demonstrated neuroprotective effects in mice with Huntington’s disease (it protects and preserves the nerves of the brain from injury, disease, and degeneration). There is currently no effective treatment for Huntington’s disease. CBG might also provide neuroprotection in patients with Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke patients.
A study from 20146 demonstrated that CBG inhibited the progression of colon cancer in mice7 and another study8 suggested that CBG might also help protect from prostate cancer. A very old study9 done on mice suggested that CBG might be effective at treating skin melanoma cells.
A study10 done in vitro suggested that CBG was the most effective cannabinoid for treating bladder dysfunctions because it decreased bladder contractions.
CBG has been shown to increase appetite in two rat-based studies conducted by researchers at the University of Reading (UK) in 201611 and 201712.
Dr. Bonni Goldstein has suggested that CBG can decrease anxiety and muscle tension, and appears to have antidepressant and some modest antifungal properties.
CBG might be a treatment for sexual dysfunction in men. Of course, reasons for sexual dysfunction are complex, and the current research is very limited. Additionally, our patients have reported success when using CBG to help treat anxiety, migraines, mild pain, and hot flashes.
Overall, CBG is very safe. It has no impairing effects, no toxic dose, no withdrawal effects, and no risk of addiction. CBG can be a safe option for use in pediatric and geriatric populations and in patients with a history of psychosis or schizophrenia.
Reprinted via MH Blog 2019
There are approximately 113 different cannabinoids that have been isolated from cannabis, and those that have been studied exhibit a variety of effects(1). In the marketplace, we have access to about six: THC, CBD, THCa, CBDa, CBN, and CBG. As technology improves and companies mature, new products featuring additional cannabinoids are beginning to become available, including products with delta-8 THC, THCv, and CBC.
The cannabinoids that have the suffix –a are called acidic cannabinoids. When acidic cannabinoids are exposed to heat or to prolonged light, they convert to an activatedcannabinoid. For example, THCa and CBDa are acidic cannabinoids, while THC and CBD are activated cannabinoids. This conversion process is called decarboxylation. Why should you care about decarboxylation? Because—while there are some overlapping therapeutic properties—some of the acidic forms of cannabinoids can have very different effects than their activated counterparts.
There is currently limited scientific information on the pharmacology and toxicology of the acidic cannabinoids. This blog will focus on CBDa, and the data that is available suggests that CBDa might be effective at treating the following conditions:
Nausea and Vomiting
A 20112 and a 20133 study both demonstrated that CBDa reduces vomiting and nausea (in fact, these studies—both done in rat models—suggested that CBDa was more effective than CBD in controlling nausea and vomiting). CBDa is also effective at treating anticipatory nausea and vomiting, which is a condition of psychological nausea and vomiting and is believed to be a learned response to chemotherapy4.
To date, there are no completed human or animal studies to test whether CBDa is a treatment for inflammatory conditions. However, research in cell cultures demonstrates that CBDa is a COX-2 inhibitor and might have similar effects as non-steroidal anti-inflammatory drugs (NSAIDS), such as ibuprofen, acetaminophen, and aspirin, which are often prescribed for inflammatory pain.
Long-term and heavy use of NSAIDS, however, can lead to stomach ulcers, kidney damage, high blood pressure, and headaches, mostly because many NSAIDS are both COX-2 and COX-1 inhibitors. Cox-1 inhibitors also reduce inflammation, but data suggests that COX-1 inhibitors decrease the protective mucus lining of the stomach, causing stomach problems, intestinal bleeding, and ulcers. CBDa is not a COX-1 inhibitor.
COX-2 activity is involved not only in inflammatory processes but also in the metastasis—or spreading—of cancer cells. Research suggests that the regular consumption of COX inhibitors might lower the rates of cancer, especially for colorectal cancer5. Research suggests that CBDa, as a COX-2 inhibitor, might reduce cancer cell proliferation, promote the natural death of diseased cells, and reduce the blood supply required for tumor growth6.
For example, a study publish in 2012 demonstrated that CBDa inhibits migration of a specific type of invasive breast cancer cell7, preventing these cancer cells from growing and dividing. And a study published in 20148 demonstrated that CBDa slowed down the spread of cancerous cells, which is especially critical in breast cancer, where metastases are responsible for 90% of breast cancer-related deaths9.
Of course, like all cannabinoids, CBDa can have side effects, though they are generally well-tolerated and dose-dependent. And, again, there exists limited scientific information on the pharmacology and toxicology of CBDa. However, based on patient feedback—and assumptions about the similarities that CBDa shares with CBD—we can expect CBDa to have side effects that include anxiety, jitteriness, diarrhea, and increased heart rate, and decreased appetite. Also, CBDa can inhibit or potentiate other medications.
Some patients find relief by juicing raw cannabis flowers that are high in CBDa. Patients can also find CBDa in tinctures and oils, which they can consume orally or use topically. Finally, there are some products that contain CBDa isolates, which means that they product was processed to remove all other cannabinoids. As with all acidic cannabinoids, it’s a good idea to keep CBDa refrigerated to prevent it from converting into an activated cannabinoid.
Many patients find that CBDa can be a potent natural pain reliever without the risk of ulcers or kidney damage. Radicle Health patients have reported that CBDa reduces inflammation, pain, and fatigue, and other patients have reported improvement with ADHD and with cognition. Also, CBDa does not cause the type of euphoria associated with THC, so patients can use CBDa during the day without any impairing side effects. As always, ensure that you work with a cannabis healthcare professional to determine which cannabinoids and which products are right for your condition or disease.
2“The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus,” Archives of Pharmacal Research, 2011, http://www.ncbi.nlm.nih.gov/pubmed/21975813
3“Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation,” British Journal of Pharmacology, 2013 Mar; 168(6): 1456–1470, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596650/
4“A comparison of cannabidiolic acid with other treatments for anticipatory nausea using a rat model of contextually elicited conditioned gaping,” Psychopharmacology, August 2014, http://www.ncbi.nlm.nih.gov/pubmed/24595502
How does CBD work?
In the last 30 years, Research on the effects cannabis on the human body led to the discovery of the ECS, or endocannabinoid system. CBD is a cannabinoid. The ECS is a complex system of cannabinoid receptors found throughout the body, but mainly in the immune and nervous systems. The ECS plays a role in communicating with, and regulating virtually every system and organ in the body. A healthy ECS enables Homeostasis, which is when our cells, organs, and physiological systems are in balance and working properly. CBD works extremely efficiently with the ECS to help maintain that homeostasis and balance across the different systems of our body. CBD helps the body heal and balance itself.
Cannabidiol, or CBD, is one of over 100 cannabinoids found in cannabis and hemp plants. CBD has been proven to have enormous medicinal and therapeutic potential. There are no negative side effects associated with taking CBD. Unlike its notorious cousin THC, CBD is non-psychoactive, meaning it does not get you “high” or leave you feeling “stoned”. From chronic pain to anxiety/depression and many things in between-CBD is helping a rapidly growing number of people find safe, natural, effective relief*. The medicinal benefits of taking CBD are nearly identical to those of medical marijuana, with the added benefit of not having to be high every time you take your medicine. Yes, you read that correctly! CBD provides virtually the same medical benefits as marijuana with no “high”! CBD provides real true Help without the High or negative side effects of other medications*.
Cliff Atwell, B.S., D.C.